Correlation Between Structure and New Anti-cancer Activity of Some Antioxidants Following Chemical Structure Modification Does The Evidence Support This Correlation

In medicinal chemistry, the link between structure and activity is essential. We are seeking to relate chemical reactivity properties, which has gained popularity recently. this study, scaffolds from three antioxidants were changed new derivatives show that their biological effects as would change. also reviewed anticancer of these medications (based on SRB test) find other may be related structural modifications. Moreover, SWISS ADME software was used determine further characteristics. Compound 2C had highest cytotoxicity (1.2 μM) against lung cancer cell lines, whereas 1C good (87.66 μM). demonstrated excellent lines with IC50 values 5.049, 6.26, 9.71 μM, respectively. After its antioxidant tweaked, might a critical molecule for building novel treatment cancer.